PT-141 10MG

What Is PT-141 10mg?

PT-141 10mg (Bremelanotide) is a research-grade cyclic heptapeptide supplied by Arma Peptides for controlled laboratory investigation. PT-141 is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) and a metabolite of Melanotan II, developed as a non-selective melanocortin receptor agonist with documented activity at MC3R and MC4R subtypes. Unlike phosphodiesterase inhibitors, the compound acts centrally via hypothalamic and limbic pathway modulation rather than through direct peripheral vascular mechanisms — a pharmacological distinction that has made PT-141 a widely cited reference compound in CNS-mediated arousal and sexual function research.

With a molecular weight of approximately 1,025.2 Da and a cyclic backbone conferring resistance to enzymatic degradation, it demonstrates a more extended activity profile than linear melanocortin peptides in preclinical models. The 10mg format supports multi-arm or longer-duration laboratory protocols. Researchers interested in the structurally related linear analogue may also consider Melanotan 2 10mg from Arma Peptides.

Mechanism of Action

PT-141 exerts its experimentally observed effects primarily through agonist activity at melanocortin receptor subtypes MC3R and MC4R, both of which are expressed in hypothalamic nuclei involved in autonomic and limbic regulation. Receptor activation initiates downstream cAMP-mediated signalling cascades that modulate dopaminergic and oxytocinergic neurotransmission in brain regions associated with motivational and arousal circuitry.

The central mechanism of action differentiates the compound from peripherally acting vasodilatory agents and has generated significant research interest in models of CNS-regulated physiological responses. MC4R agonism has also been investigated in the context of energy homeostasis and feeding behaviour, broadening its utility as a research tool beyond a single biological domain.

PT-141 10mg Research Overview

PT-141 10mg has been studied extensively in preclinical models examining melanocortin receptor pharmacology, CNS arousal pathways, and hypothalamic neuromodulation. Early research established its activity profile relative to α-MSH and MTII, documenting receptor selectivity and behavioural correlates in rodent models. Subsequent studies examined dose-response characteristics, receptor subtype contributions, and interactions with dopaminergic systems.

Research has also explored the compound’s involvement in energy balance regulation via MC4R-mediated pathways in the arcuate nucleus. Structural and pharmacological data are indexed at PubChem (NIH), bioactivity records are available in the ChEMBL database (EMBL-EBI), and peer-reviewed literature is indexed at NCBI.

Research Applications

PT-141 10mg is referenced across multiple experimental disciplines. Documented research applications include:

• MC3R and MC4R receptor binding affinity and selectivity characterisation
• Hypothalamic arousal pathway and limbic neuromodulation studies
• Dopaminergic and oxytocinergic neurotransmission research in CNS models
• Comparative melanocortin pharmacology alongside α-MSH and Melanotan II
• Energy homeostasis and feeding behaviour investigations via MC4R
• cAMP signalling cascade characterisation in melanocortin receptor models
• CNS-mediated autonomic pathway modulation research
• Cyclic peptide stability and pharmacokinetic profiling studies

Product Specifications

Storage & Handling

Store at –20°C in the original sealed vial, protected from light and moisture. Once reconstituted for experimental use, aliquots should be kept at 4°C and used within an appropriate timeframe in accordance with standard peptide handling protocols. Reconstitution is typically performed using sterile or bacteriostatic water. All laboratory handling must comply with applicable institutional biosafety guidelines and relevant regulatory requirements.

Related Research Peptides

Researchers working in melanocortin receptor, CNS arousal, or neuropeptide models may also find the following Arma Peptides compounds relevant:

• Melanotan 2 10mg — structurally related cyclic α-MSH analogue for comparative melanocortin receptor research
• Melanotan 2 Acetate 10mg — acetate salt form of Melanotan II for melanocortin pharmacology studies
• Selank 10mg — anxiolytic neuropeptide investigated in CNS neuromodulation research
• DSIP 5mg — neuropeptide studied in hypothalamic and sleep-wake cycle regulation models

Research Disclaimer

PT-141 10mg is supplied by Arma Peptides strictly for controlled scientific research. Not intended for human or veterinary use. All handling must comply with applicable institutional and regulatory guidelines.