Sermorelin 10MG

What Is Sermorelin 10mg?

Sermorelin 10mg is a research-grade lyophilised peptide supplied by Arma Peptides for controlled laboratory investigation. Sermorelin (GHRH 1–29 NH₂) is a synthetic 29-amino acid analogue representing the biologically active N-terminal fragment of endogenous growth hormone-releasing hormone (GHRH 1–44). The compound retains full GHRH receptor agonist activity despite lacking the C-terminal 15 residues of native GHRH, making it the shortest GHRH fragment with documented full intrinsic efficacy at the pituitary GHRH receptor (GHRHR).

With a molecular weight of approximately 3,357.9 Da, the compound has been extensively used as a reference GHRH analogue in endocrine research, particularly in studies examining pulsatile GH secretion, somatotroph function, and GH axis feedback regulation. The 10mg format is suited to multi-arm or longer-duration preclinical protocols. Researchers may also consider pairing with Ipamorelin 10mg for combinatorial GH axis studies.

Mechanism of Action

Sermorelin acts as a selective agonist at the pituitary GHRH receptor (GHRHR), a G-protein-coupled receptor expressed on somatotroph cells. Receptor binding activates adenylyl cyclase via Gs-protein coupling, elevating intracellular cAMP and triggering protein kinase A (PKA)-mediated signalling cascades. This results in both acute GH secretion and, with repeated stimulation, upregulation of GH gene transcription and somatotroph proliferation in experimental models.

The compound’s mechanism is distinct from growth hormone secretagogues such as ipamorelin and GHRP-6, which act via the ghrelin receptor (GHSR-1a). The two receptor systems are functionally synergistic in preclinical models, providing additive or supra-additive GH release when combined — a property that has made sermorelin a common comparator in GHS combination research.

Sermorelin 10mg Research Overview

Sermorelin 10mg has an established preclinical research record spanning GH axis pharmacology, neuroendocrinology, and age-related metabolic biology. Studies have examined its role in restoring pulsatile GH secretion in GH-deficient rodent models, characterising GHRHR binding kinetics, and investigating downstream IGF-1 pathway responses. Research in aged animal models has documented partial restoration of GH pulse amplitude and frequency, generating interest in its utility as a GH axis research reference compound.

Further studies have investigated the compound in body composition, bone density, and sleep architecture research in preclinical models. Structural and pharmacological data are indexed at PubChem (NIH), bioactivity records are available in the ChEMBL database (EMBL-EBI), and peer-reviewed literature is indexed at NCBI.

Research Applications

Sermorelin 10mg is referenced across multiple experimental disciplines. Documented research applications include:

• GHRH receptor binding kinetics and Gs-protein signalling characterisation
• Pulsatile GH secretion dynamics and somatotroph function studies
• IGF-1 pathway modulation and downstream anabolic signalling research
• GH axis restoration in GH-deficient and aged animal models
• Bone density and growth plate biology in endocrine research
• Body composition and metabolic rate investigations in rodent models
• Combinatorial GH secretagogue studies alongside GHSR-1a agonists
• Sleep architecture and slow-wave sleep regulation research

Product Specifications

Storage & Handling

Store at –20°C in the original sealed vial, protected from light and moisture. Once reconstituted for experimental use, aliquots should be kept at 4°C and used within an appropriate timeframe in accordance with standard peptide handling protocols. Reconstitution is typically performed using sterile or bacteriostatic water. All laboratory handling must comply with applicable institutional biosafety guidelines and relevant regulatory requirements.

Related Research Peptides

Researchers working in GH axis, endocrine, or metabolic models may also find the following Arma Peptides compounds relevant:

• Ipamorelin 10mg — selective GHSR-1a agonist frequently combined with GHRH analogues in GH axis research
• Ipamorelin 5mg — smaller-format GHSR-1a agonist for initial or single-arm protocols
• CJC-1295 No DAC 10mg — GHRH analogue with short half-life for pulsatile GH secretion studies
• CJC-1295 with DAC 10mg — long-acting GHRH analogue for sustained GH axis stimulation research

Research Disclaimer

Sermorelin 10mg is supplied by Arma Peptides strictly for controlled scientific research. Not intended for human or veterinary use. All handling must comply with applicable institutional and regulatory guidelines.