Tesamorelin 10MG

Tesamorelin 10mg is a lyophilised research peptide supplied as a white to off-white powder in a sealed, nitrogen-purged vial. A stabilised synthetic analogue of human growth hormone-releasing hormone (GHRH), Tesamorelin 10mg consists of the full 44-amino acid GHRH sequence with a trans-3-hexenoic acid moiety conjugated to the N-terminus, increasing plasma half-life and resistance to dipeptidyl peptidase-IV (DPP-IV) cleavage. Arma Peptides supplies Tesamorelin 10mg at ≥99% purity, confirmed by third-party HPLC and mass spectrometry. Full batch CoA documentation is available on our Certificate of Analysis page. For research use only.

What Is Tesamorelin?

Tesamorelin is a synthetic GHRH analogue developed to study the hypothalamic-pituitary axis and endogenous growth hormone regulation. It binds selectively to pituitary GHRH receptors, stimulating pulsatile GH secretion and downstream IGF-1 production. Unlike exogenous recombinant GH, Tesamorelin acts through physiological feedback mechanisms, preserving the natural pulsatile pattern of GH release. Its molecular formula is C₂₂₃H₃₇₀N₇₂O₆₉S with a molecular weight of approximately 5,196 g/mol. Full compound data is available via the PubChem entry for Tesamorelin (CID 16137828). The compound is also catalogued on ChEMBL as CHEMBL1237026.

Mechanism of Action

Tesamorelin binds to growth hormone-releasing hormone receptors (GHRHR) expressed on somatotroph cells in the anterior pituitary. Receptor activation triggers intracellular cAMP accumulation via Gs protein coupling, leading to GH synthesis and secretion. Released GH subsequently stimulates hepatic IGF-1 production, which mediates downstream anabolic and metabolic effects. Because Tesamorelin acts upstream of GH itself, the normal negative feedback loop through somatostatin remains intact — a key advantage for preclinical mechanistic studies compared to direct GH administration.

Research Areas

Tesamorelin 10mg is used across several areas of preclinical and translational research:

• GH axis pharmacology — pituitary GHRHR binding kinetics, GH pulsatility modelling, and cAMP signalling assays
• Metabolic research — visceral adipose tissue regulation, lipid metabolism, and hepatic fat accumulation models
• IGF-1 signalling — downstream insulin-like growth factor pathway investigation in tissue culture models
• Neuropeptide stability — DPP-IV resistance and plasma half-life studies compared to native GHRH(1–44)

Key published research includes a PMC study on the effects of a GHRH analogue on endogenous GH pulsatility (PMC3038486), which provides mechanistic context for Tesamorelin’s pituitary activity in experimental settings.

Supplied Format & Specification

Purity & Quality Assurance

Every batch of Tesamorelin 10mg supplied by Arma Peptides is independently tested before dispatch. Purity is confirmed at ≥99% by HPLC with identity verification by mass spectrometry. Batch-specific certificates are published on our laboratory tests page. We do not release stock without passing quality thresholds.

Storage Conditions

Store lyophilised Tesamorelin 10mg at −20°C in a dry, dark environment. Avoid freeze-thaw cycling to maintain peptide integrity. For in vitro reconstitution, use sterile aqueous buffer appropriate to the assay and aliquot immediately. Store reconstituted working solutions at −80°C for short-term use.

Related Research Peptides

Researchers studying the GH axis and peptide secretagogues often pair Tesamorelin 10mg with complementary compounds. Browse related products available from Arma Peptides:

• Ipamorelin 5mg — selective GHRP with minimal prolactin or cortisol release
• Ipamorelin 10mg — higher-dose format for extended in vitro protocols
• GHRP-6 5mg — hexapeptide GH secretagogue, widely used in GH pulsatility research
• CJC-1295 No DAC 10mg — short-acting GHRH analogue for pulsatile GH release studies
• CJC-1295 with DAC 10mg — extended half-life GHRH analogue for sustained GH elevation protocols
• HGH 100 IU — recombinant human growth hormone for comparative GH research

This product is intended for laboratory research purposes only. Not for human or veterinary use. Not for resale. Must be handled by qualified researchers in appropriate laboratory conditions.