Ipamorelin 10MG

What Is Ipamorelin 10mg?

Ipamorelin 10mg is a research-grade lyophilised pentapeptide supplied by Arma Peptides for controlled laboratory investigation. Ipamorelin (Ala-His-D-2-Nal-D-Phe-Lys-NH₂) is a synthetic growth hormone secretagogue (GHS) and selective ghrelin receptor agonist developed as an analogue of GHRP-1. The compound is characterised by high selectivity for GH release with markedly lower stimulation of cortisol, prolactin, and ACTH compared to earlier GHRP compounds — a pharmacological profile that has made it a widely used reference peptide in endocrine and metabolic research.

With a molecular weight of approximately 711.9 Da and a five-residue sequence, ipamorelin demonstrates favourable stability in aqueous environments relative to endogenous ghrelin. The 10mg format is suited to multi-arm or longer-duration preclinical protocols. Researchers requiring a smaller starting quantity may also consider Ipamorelin 5mg from Arma Peptides.

Mechanism of Action

Ipamorelin acts primarily as an agonist at the growth hormone secretagogue receptor 1a (GHSR-1a), also known as the ghrelin receptor, expressed in the pituitary gland and hypothalamus. Binding to GHSR-1a stimulates GH release via a calcium-dependent, cAMP-independent intracellular pathway, distinct from GHRH-mediated signalling. This dual-pathway independence allows the compound to act synergistically with GHRH analogues in experimental models.

The selectivity of ipamorelin for GH secretion without concomitant elevations in cortisol or prolactin distinguishes it mechanistically from GHRP-2 and GHRP-6 in laboratory comparisons. Its activity profile has been confirmed in multiple in vitro pituitary cell models and in vivo rodent studies, making it a standard reference compound for GHS receptor pharmacology research.

Ipamorelin 10mg Research Overview

Ipamorelin 10mg is a well-characterised research tool across endocrinology, bone biology, and metabolic science. Preclinical studies have investigated its role in GH axis modulation, pulsatile GH secretion dynamics, and downstream IGF-1 pathway activity. In rodent models, the compound has been shown to increase GH pulse amplitude without significantly altering pulse frequency — a finding of relevance to endocrine rhythm research.

Additional research has examined the compound in bone density and growth plate studies, particularly in models of GH deficiency. Structural and pharmacological data are indexed at PubChem (NIH), bioactivity records are available in the ChEMBL database (EMBL-EBI), and peer-reviewed literature is indexed at NCBI.

Research Applications

Ipamorelin 10mg is referenced across multiple experimental disciplines. Documented research applications include:

• GH axis modulation and pulsatile growth hormone secretion studies
• GHSR-1a receptor binding and selectivity characterisation
• IGF-1 pathway activity and downstream anabolic signalling research
• Bone density and growth plate biology in GH-deficient models
• Metabolic rate and body composition investigations in rodent models
• Comparative GHS pharmacology alongside GHRP-2, GHRP-6, and CJC-1295
• Cortisol and prolactin selectivity studies in pituitary cell models
• Appetite regulation and ghrelin receptor signalling research

Product Specifications

Storage & Handling

Store at –20°C in the original sealed vial, protected from light and moisture. Once reconstituted for experimental use, aliquots should be kept at 4°C and used within an appropriate timeframe in accordance with standard peptide handling protocols. Reconstitution is typically performed using sterile or bacteriostatic water. All laboratory handling must comply with applicable institutional biosafety guidelines and relevant regulatory requirements.

Related Research Peptides

Researchers working in GH axis, endocrine, or metabolic models may also find the following Arma Peptides compounds relevant:

• Ipamorelin 5mg — smaller-quantity format for initial or single-arm laboratory protocols
• CJC-1295 No DAC 10mg — GHRH analogue frequently paired with ipamorelin in GH axis research
• CJC-1295 with DAC 10mg — long-acting GHRH analogue for extended GH secretion studies
• GHRP-6 5mg — hexapeptide GH secretagogue for comparative GHSR pharmacology research

Research Disclaimer

Ipamorelin 10mg is supplied by Arma Peptides strictly for controlled scientific research. Not intended for human or veterinary use. All handling must comply with applicable institutional and regulatory guidelines.